Positive inotropic agent with vasodilating activity
Specification – pharmacopeia: In House
Therapeutic category: cardiotonic
Treatment: Adjuvant for treatment of chronic cardiac insufficiency and cardiac insufficiency post-stroke.
Levosimendan increases the sensibility of cardiac contractile proteins for Ca2+ ions, through Cardiac Troponin C (cTnC) binding, increasing the contractile force and opens the ATP sensitive canal in the vascular smooth muscle,
allowing the vase-dilatation inside arteries.