DIAZOXIDE
Antyhypertensive and hyperglucemiant agent, derived from benzothiadiazine
Specification – pharmacopeia: EP, USP
Therapeutic category: antihypoglycemic & antihypertensive
Treatment: for human applications, diazoxide is indicated in the treatment of hypertension and hypoglycemia.
Pharmacology:
Diazoxide presents the antihypertensive effect through its action on the large-conductance calcium-activated potassium (KCa) channel, which relaxes
the smooth muscle.
For the hyperglycemia effect, Diazoxide inhibits secretion of insulin from pancreatic beta cells, by opening potassium channels in the
beta cell membrane, which allows to increase the level of glucose in blood.
Aplicación: human
CAS number: 364-98-7
Chemical formula: C8H7ClN2O2S
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